January 12, 1971Acta Medica Scandinavica

Platelet Function and Platelet Phospholipids in Patients With Hyperbetalipoproteinemia

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Why the study?

Does treatment with nicotinic acid or clofibrate improve platelet factor-3 activity and lipid profiles in patients with hyperbetalipoproteinemia?

Population

Patients with hyperbetalipoproteinemia

Comparison

Treatment with nicotinic acid or clofibrate vs Baseline (before treatment)

Design

Cohort

Authors

ANArne NordøyUiT The Arctic University of Norway JRJohanne Margrete RødsetOslo University Hospital

Discussion

Member takes

Implication

May suggest antithrombotic benefit in hyperbetalipoproteinemia; leaves open confirmation in randomized trials.

Structured PICO

Does treatment with nicotinic acid or clofibrate improve platelet factor-3 activity and lipid profiles in patients with hyperbetalipoproteinemia?

Population

Patients with hyperbetalipoproteinemia

Intervention

Treatment with nicotinic acid or clofibrate

Comparator

Baseline (before treatment)

Outcome

Platelet factor-3 activity and availability, platelet phospholipids, their fatty acid and aldehyde composition, and plasma lipidssurrogate

Treatment with nicotinic acid or clofibrate normalizes platelet factor-3 activity in patients with hyperbetalipoproteinemia, potentially reducing their tendency for thrombosis.

Cite This Study

Nordøy et al. (1971) studied this question.

synapsesocial.com/papers/6a85ba324f2eb4dbc91e6c36 https://doi.org/10.1111/j.0954-6820.1971.tb04395.x

View Full Paper

Ask AI

Bookmark

Platelet Function and Platelet Phospholipids in Patients With Hyperbetalipoproteinemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Platelet Function and Platelet Phospholipids in Patients With Hyperbetalipoproteinemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider