Patients with non-acute ischemic heart disease exhibit increased platelet factor-3 activity and altered platelet phospholipid composition compared to controls.
These platelet changes may heighten thrombotic risk in non-acute IHD; hypothesis-generating and should not yet alter management.
Platelet factor‐3 activity and availability, platelet phospholipids and their fatty acid and aldehyde composition have been examined in males with non‐acute ischemic heart disease and in a control group. Increased platelet factor‐3 activity was present in platelet‐rich but not in platelet‐poor plasma from the patients. No difference in the increase of activity after exposure of PRP to ADP, kaolin or freezing and thawing three times was observed compared with the controls. Estimated per 10° platelets, increased amounts of ethanolamine glycerides, serine phosphoglycerides, choline phosphoglycerides, sphingomyeline and total lipid phosphorus were found in the patient group. The phospholipid: protein ratio was also increased. Only small changes were observed in the fatty acid pattern of the various phospholipids. A slight decrease in palmitic acid and a slight increase in oleic acid were found in most fractions.
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Nordøy et al. (1970) studied this question.
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