Metallomacrocycle 2 , possessing an immobilized Lewis‐acidic uranyl cation, was synthesized by reaction of aldehyde 9 with 1,2‐ cis ‐cyclohexanediamine in the presence of Ba 2+ as a template cation and subsequent transmetallation with UO 2 2+ . Docking experiments with barbituric acid revealed that a ‐(CH 2 ) 6 – spacer between the salen‐uranyl and 2,6‐diamidopyridine moieties of 2 is optimal. According to 1 H NMR titration experiments, the barbituric acid complex of 2 is up to 2.7 kcal · mol −1 more stable than the complexes with five disubstituted derivatives. The flux of barbituric acid through a supported liquid membrane is enhanced 3.7 times by carrier 2 mediated transport.
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Doorn et al. (1992) studied this question.
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