What question did this study set out to answer?

To evaluate the clinical efficacy and safety of cefamandole as a single antimicrobial agent in patients with acute bacterial peritonitis.

May 1, 1978The Journal of Infectious Diseases

Cefamandole in Treatment of Peritonitis

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Authors

HSH. H. StoneUniversity of Phoenix BGBRYGIDA GUESTEmory University CGCAROL E. GEHEBEREmory University

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Implication

Clinical evaluation reveals high clinical cure rates with intravenous cefamandole monotherapy in bacterial peritonitis, indicating its efficacy for managing acute intra-abdominal infections.

Key Points

To evaluate the clinical efficacy and safety of cefamandole as a single antimicrobial agent in patients with acute bacterial peritonitis.
Administered intravenous cefamandole (1 to 2 g every 6 hours) as monotherapy to N=113 patients presenting with bacterial peritonitis.
Performed surgical intervention via laparotomy in 99 patients alongside in vitro disk diffusion and tube dilution susceptibility testing.
Achieved a favorable clinical response in 107 of 113 patients (95%), with overall mortality in 6 patients and only 1 death attributable to infection.
Demonstrated in vitro susceptibility in 91% of gram-negative rods and 61% of anaerobes, with infusion-site phlebitis occurring in 13 patients (12%) and no detected hepatic, renal, or hematopoietic toxicities.

Cite This Study

Stone et al. (1978) studied this question.

synapsesocial.com/papers/6a85c99502ac45e32cc93068 https://doi.org/10.1093/infdis/137.supplement.s103

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Implication

Clinical evaluation reveals high clinical cure rates with intravenous cefamandole monotherapy in bacterial peritonitis, indicating its efficacy for managing acute intra-abdominal infections.

Cefamandole in Treatment of Peritonitis

Discussion

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Implication

Key Points

Cite This Study

Cefamandole in Treatment of Peritonitis

Discussion

Member takes

Implication

Key Points

Cite This Study

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