Why the study?
Does a five-dose regimen of cefamandole reduce wound infections compared to a single preoperative dose in patients undergoing internal fixation surgery?
Population
717 patients undergoing an operation using either a Moore prosthesis, Ender or Küntscher nails, a bone…
Comparison
Five doses of cefamandole (group I, n=335) vs A single preoperative dose of cefamandole
Design
RCT, Randomized, Double-blind
Authors
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Supports multi-dose cefamandole prophylaxis in internal fixation; extends evidence favoring extended over single-dose perioperative antibiotics.
Does a five-dose regimen of cefamandole reduce wound infections compared to a single preoperative dose in patients undergoing internal fixation surgery?
A five-dose regimen of perioperative cefamandole significantly reduced the rate of wound infections compared to a single preoperative dose in patients undergoing internal fixation surgery.
Gatell et al. (1987) studied this question.
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