Key result
Two perioperative doses of cefotiam significantly reduced the rates of major (5% vs 1%) and minor (11% vs 4%) wound infections compared to placebo in patients with hip fractures (p < 0.05).
Why the study?
Does cefotiam reduce wound infection in patients with hip fractures managed with internal fixation?
Population
239 patients who had immediate stabilization of a fracture of the proximal part of the femur with a dynamic…
Comparison
Two perioperative doses of cefotiam, given… vs Two doses of a placebo
Design
RCT, randomized, double-blind
Follow-up
minimum of six weeks
Authors
Loading...
Two-dose cefotiam prophylaxis cuts wound infections after dynamic hip screw fixation; reinforces perioperative antibiotics as standard in proximal femur fracture surgery.
RCT (n=239)
Double-blind
randomized
Does cefotiam reduce wound infection in patients with hip fractures managed with internal fixation?
Absolute Event Rate: 1% vs 5%
p-value: p=< 0.05
Two perioperative doses of cefotiam significantly reduce the rate of major and minor wound infections in patients undergoing internal fixation for hip fractures.
Bodoky et al. (1993) conducted an RCT in Fracture of the proximal part of the femur (n=239). Cefotiam vs. Placebo was evaluated on Major wound infection (p=< 0.05). Two perioperative doses of cefotiam significantly reduced the rates of major (5% vs 1%) and minor (11% vs 4%) wound infections compared to placebo in patients with hip fractures (p < 0.05).