Why the study?
Does perioperative administration of cephalothin prevent postoperative infection in patients with a fracture of the proximal part of the femur?
Population
307 patients with a fracture of the proximal part of the femur
Comparison
Perioperative administration of cephalothin vs Control group
Design
RCT, Randomized, Double-blind
Authors
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Supports perioperative cephalothin to reduce major wound infections after hip fracture; confirms antibiotic prophylaxis benefit in orthopedic trauma.
Does perioperative administration of cephalothin prevent postoperative infection in patients with a fracture of the proximal part of the femur?
Perioperative cephalothin significantly reduces major postoperative wound infections in patients with hip fractures, though it may increase colonization by resistant organisms.
Burnett et al. (1980) studied this question.
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