Key result
A single preoperative 1 g dose of ceftriaxone was as effective as a 3-day regimen of cefotaxime for preventing infection after peritrochanteric fracture surgery, with 1 infection in each group.
Why the study?
Does a single preoperative dose of ceftriaxone prevent infection as effectively as a multi-dose regimen of cefotaxime in patients undergoing orthopedic surgery for peritrochanteric fractures?
RCT (n=200)
Does a single preoperative dose of ceftriaxone prevent infection as effectively as a multi-dose regimen of cefotaxime in patients undergoing orthopedic surgery for peritrochanteric fractures?
Absolute Event Rate: 1% vs 1%
A single preoperative dose of ceftriaxone is as effective as a 3-day multi-dose regimen of cefotaxime for infection prophylaxis in orthopedic surgery, offering practical advantages for nursing care.
No takes yet. Share an insight, caveat, or question.
May support single-dose ceftriaxone prophylaxis in peritrochanteric fracture surgery; hypothesis-generating and requires RCT confirmation before practice change.
Karachalios et al. (2009) conducted an RCT in Peritrochanteric Fractures (n=200). Ceftriaxone vs. Cefotaxime 1 g preoperatively and every 8 h for 3 days (9 doses total) was evaluated on Deep wound infection at 1-year follow-up. A single preoperative 1 g dose of ceftriaxone was as effective as a 3-day regimen of cefotaxime for preventing infection after peritrochanteric fracture surgery, with 1 infection in each group.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: