Why the study?
Does immunoglobulin prophylaxis prevent hepatitis A in exposed or at-risk individuals?
Population
Individuals exposed to or at risk of hepatitis A
Design
Review
Authors
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Supports early immunoglobulin for hepatitis A exposure; leaves open updated vaccine comparisons in current cohorts.
Does immunoglobulin prophylaxis prevent hepatitis A in exposed or at-risk individuals?
Immunoglobulin is highly effective (80-90%) at preventing hepatitis A when given early, providing a benchmark for evaluating emerging hepatitis A vaccines.
Winokur et al. (1992) studied this question.
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