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December 31, 2012Archives of Pathology & Laboratory Medicine

Multiple Factors Contribute to Positive Results for Hepatitis A Virus Immunoglobulin M Antibody

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Population

Patients who underwent testing for immunoglobulin M antibody to hepatitis A virus between January 2007 and…

Design

Cohort

Authors

AAAdnan AlatoomDubai Health AuthorityMAM. Qasim AnsariLouis Stokes Cleveland VA Medical CenterJCJennifer A. CuthbertThe University of Texas Southwestern Medical Center

Discussion

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Overview

Low IgM HAV yield signals overuse; CPOE-linked reductions remain hypothesis-generating pending prospective validation.

Structured PICO

P
Population
Patients who underwent testing for immunoglobulin M (IgM) antibody to hepatitis A virus (HAV) between January 2007 and December 2010, yielding 10,735 tests and 35 patients with 49 positive results.
I
Intervention
Review of positive HAV IgM test results and the introduction of computerized physician order entry.
O
Outcome
Categorization of positive results (acute, recent, resolved, or indeterminate HAV infection) and the effect of changing ordering options on test volume.

Current assays for IgM HAV antibodies are overused in the absence of clinical acute hepatitis, and computerized physician order entry can significantly reduce unnecessary testing.

Cite This Study

Alatoom et al. (2012) studied this question.

synapsesocial.com/papers/6a926df05ab1441fe3c81a11https://doi.org/10.5858/arpa.2011-0693-oa
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnosis of Acute Hepatitis A by HAVAB®-M, a Direct Radioimmunoassay for IgM Anti-HAV1981 · 60 citations
  2. 2Sensitive assays for hepatitis a antibodies1993 · 47 citations
  3. 3Use of Serological Assays for Diagnosis of Hepatitis E Virus Genotype 1 and 3 Infections in a Setting of Low Endemicity2007 · 112 citations
  4. 4Diagnosis of Hepatitis A Virus Infection: a Molecular Approach2006 · 395 citations
  5. 5The Persistence of Hepatitis A IgM Antibody After Acute Clinical Hepatitis A†1984 · 123 citations