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August 1, 1979The Journal of Infectious Diseases

A Solid-Phase Radioimmunoassay for Detection of IgM Antibodies to Hepatitis A Virus

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Population

Sera from patients with hepatitis, and 50 control sera positive for rheumatoid factor or other viral…

Design

Other

Follow-up

up to 12 months

Authors

BFBertram FlehmigCS DiagnosticsMRMichael B. RankeUniversity Children's Hospital TübingenHBHeiner K. BertholdUniversity Hospital Bonn

Discussion

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Overview

May support timing recent HAV diagnosis via IgM; leaves open prospective validation before clinical adoption.

Structured PICO

P
Population
Sera from patients with hepatitis, and 50 control sera positive for rheumatoid factor or other viral infections (HBV, CMV, infectious mononucleosis, influenza A, rubella, measles).
I
Intervention
Solid-phase radioimmunoassay (RIA) for detection of IgM antibodies to hepatitis A virus (HAV)
O
Outcome
Detection of IgM antibodies to HAV (sensitivity and specificity)surrogate

The developed solid-phase RIA is a sensitive and specific method for detecting IgM antibodies to hepatitis A virus, useful for diagnosing recent infection.

Cite This Study

Flehmig et al. (1979) studied this question.

synapsesocial.com/papers/6a825644f10a9fcdd646cc34https://doi.org/10.1093/infdis/140.2.169
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serodiagnosis of viral hepatitis A: detection of acute-phase immunoglobulin M anti-hepatitis A virus by radioimmunoassay1977 · 102 citations
  2. 2Seroepidemiological investigation of patients and family contacts in an epidemic of hepatitis A1977 · 84 citations
  3. 3Detection of Hepatitis a Viral Antigen by Radioimmunoassay1975 · 121 citations
  4. 4The Antibody Response Following Hepatitis A Infection1977 · 75 citations
  5. 5A Microtiter Solid-Phase Radioimmunoassay for Hepatitis a Antigen and Antibody1976 · 222 citations