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January 1, 1979Journal of Clinical MicrobiologyOpen Access

Serodiagnosis of viral hepatitis A by a modified competitive binding radioimmunoassay for immunoglobulin M anti-hepatitis A virus

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Why the study?

Does a modified competitive binding radioimmunoassay accurately detect and differentiate acute and convalescent anti-hepatitis A virus antibodies compared to standard solid-phase radioimmunoassay?

Population

Sera samples for testing anti-hepatitis A virus antibodies

Comparison

Modified competitive binding radioimmunoassay… vs Standard solid-phase radioimmunoassay

Design

Other

Authors

DBDaniel W. BradleyEcological Society of AmericaHFHoward A. FieldsCenters for Disease Control and PreventionKMKaren A. McCaustlandCenters for Disease Control and Prevention

Discussion

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Overview

May aid acute HAV serodiagnosis; leaves open routine adoption pending modern assay comparisons.

Structured PICO

Does a modified competitive binding radioimmunoassay accurately detect and differentiate acute and convalescent anti-hepatitis A virus antibodies compared to standard solid-phase radioimmunoassay?

P
Population
Sera samples for testing anti-hepatitis A virus antibodies
I
Intervention
Modified competitive binding radioimmunoassay (CBA) with S. aureus cells (protein A) absorption
C
Comparator
Standard solid-phase radioimmunoassay
O
Outcome
Concordance of CBA and solid-phase radioimmunoassay test results for detection of anti-HAVsurrogate

A modified competitive binding radioimmunoassay can accurately detect and differentiate acute (IgM) and convalescent (IgG) hepatitis A virus antibodies.

Cite This Study

Bradley et al. (1979) studied this question.

synapsesocial.com/papers/6a8513edde619cf7bcde12f3https://doi.org/10.1128/jcm.9.1.120-127.1979
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serodiagnosis of viral hepatitis A: detection of acute-phase immunoglobulin M anti-hepatitis A virus by radioimmunoassay1977 · 102 citations
  2. 2Specific Immune Adherence Assay for Human Hepatitis A Antibody. Application to Diagnostic and Epidemiologic Investigations1975 · 173 citations
  3. 3Preliminary Serologic Studies of Antibody to Hepatitis A Virus in Populations in the United States1976 · 52 citations
  4. 4A Microtiter Solid-Phase Radioimmunoassay for Hepatitis a Antigen and Antibody1976 · 222 citations
  5. 5Hepatitis A: Report of a Common-Source Outbreak with Recovery of a Possible Etiologic Agent. II. Laboratory Studies1975 · 75 citations