Why the study?
Does Para-amino-benzene-sulfonamide (Prontylin) cause acidosis in treated patients?
Does Para-amino-benzene-sulfonamide (Prontylin) cause acidosis in treated patients?
Administration of Para-amino-benzene-sulfonamide (Prontylin) is associated with a drop in plasma CO2 combining power and can lead to clinical acidosis.
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Prontylin may cause acidosis; this case series leaves open the need for controlled confirmation before practice change.
Two cases of clinical acidosis due to the administration of Prontylin (Para-amino-benzene-sulfonamide) in large doses are reported. Fifteen consecutive cases treated with this drug showed a consistent though variable drop in the CO2 combining power of their blood plasma.
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Southworth et al. (1937) studied this question.
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