Why the study?
NT-proBNP is related to chronic kidney disease even in cases without heart failure, prompting investigation of its levels in CKD with and without diabetes, echocardiographic abnormality, and hypertension.
In patients with stage 3-4 chronic kidney disease without heart failure, NT-proBNP levels are primarily driven by the severity of renal impairment rather than the presence of diabetes, hypertension, or echocardiographic abnormalities.
Objective: Increased NT-proBNP level is a diagnostic sign for heart failure and is associated with cardiovascular mortality. It is related to chronic kidney disease (CKD) in also cases without heart failure. In this study, the authors aimed to investigate NT-proBNP levels in CKD cases with and without diabetes, echocardiographic abnormality, and hypertension. Methods: Sixty-four cases (26 diabetic and 38 non-diabetic) with stage 3-4 CKD were investigated in the study. Blood pressure values were measured on the right arm after resting for at least 5 minutes. M-mode two-dimensional echocardiography device and ultrasonography were used to evaluate cardiac and renal findings. Blood samples were taken for biochemical, hematological, hormonal and serological parameters of the patients after 12 hours of fasting. Nt-proBNP levels were measured by Elecys ProBNP sandwich immunoassay method in the Biochemistry laboratory. Results: NT-proBNP levels were not statistically different according to the presence and absence of diabetes (p=0.821) in CKD cases. However, stage-4 CKD had significantly higher NT-proBNP level than stage-3 CKD in both diabetic (p
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Güneş et al. (2025) studied this question.
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