Population
Transiently DNA-transfected cells superinfected with influenza virus
Comparison
Mutational analysis of vRNA sequences vs Wild-type vRNA sequences
Design
Preclinical
Authors
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Extends ds vRNA promoter models in animal influenza studies; leaves open any clinical or cardiovascular translation.
Mutations in influenza virus vRNA promoter elements can enhance gene expression, supporting a double-stranded vRNA promoter structure model for viral polymerase binding.
Neumann et al. (1995) studied this question.
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