October 1, 1994CirculationOpen Access

Beneficial effects of metoprolol treatment in congestive heart failure. Reversal of sympathetic-induced alterations of immunologic function.

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Why the study?

Does metoprolol improve immunologic function in patients with NYHA class III-IV congestive heart failure secondary to dilated cardiomyopathy?

Population

15 patients with New York Heart Association class III-IV congestive heart failure secondary to dilated…

Comparison

Metoprolol titrated to a minimum dose of 25 mg… vs Traditional medications without metoprolol.

Design

Cohort

Follow-up

6 months to 1 year

Authors

AMAlan MaiselUniversity of California, San Diego

Discussion

Member takes

Implication

Metoprolol was associated with restored T-cell function in advanced HF; hypothesis-generating and requires RCTs before any practice change.

Structured PICO

Does metoprolol improve immunologic function in patients with NYHA class III-IV congestive heart failure secondary to dilated cardiomyopathy?

Population

15 patients with New York Heart Association class III-IV congestive heart failure secondary to dilated cardiomyopathy, plus an additional control population of patients with heart failure.

Intervention

Metoprolol titrated to a minimum dose of 25 mg BID on a background therapy of digoxin, diuretic, and angiotensin-converting enzyme inhibitors.

Comparator

Traditional medications without metoprolol (patients also served as their own controls before treatment).

Outcome

Immunologic function measured by a panel of seven delayed hypersensitivity skin tests (anergy vs response).surrogate

Metoprolol treatment in patients with dilated cardiomyopathy enhances cell-mediated immunity and T-cell function, which correlates with improved ejection fraction.

Cite This Study

Alan Maisel (1994) studied this question.

synapsesocial.com/papers/6a864878da4bf993812ed1bc https://doi.org/10.1161/01.cir.90.4.1774

Topics

HFrEF treatment Heart failure

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Implication

Metoprolol was associated with restored T-cell function in advanced HF; hypothesis-generating and requires RCTs before any practice change.

Beneficial effects of metoprolol treatment in congestive heart failure. Reversal of sympathetic-induced alterations of immunologic function.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Beneficial effects of metoprolol treatment in congestive heart failure. Reversal of sympathetic-induced alterations of immunologic function.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider