The glomerular filtration barrier in the spontaneously hypertensive rat.
Why the study?
Are there structural differences in the glomerular filtration barrier between spontaneously hypertensive rats and normotensive WKY rats?
Population
Spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats
Comparison
Scanning and transmission electron microscopy… vs Wistar-Kyoto (WKY) rats
Design
Preclinical
Authors
Discussion
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Implication
May implicate early glomerular barrier defects in hypertension models; hypothesis-generating for human translation, requiring prospective validation.
Structured PICO
Are there structural differences in the glomerular filtration barrier between spontaneously hypertensive rats and normotensive WKY rats?
P
Population
Spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats
I
Intervention
Scanning and transmission electron microscopy and latex perfusion of the glomerular vasculature
C
Comparator
Wistar-Kyoto (WKY) rats
O
Outcome
Differences in renal structure (glomerular endothelial fenestrae diameter and density, afferent arteriolar constriction)surrogate
Structural abnormalities in the glomerular filtration barrier and afferent arterioles of spontaneously hypertensive rats may contribute to the development and maintenance of hypertension.
Cite This Study
Evan et al. (1981) studied this question.