Why the study?
Does cardiopulmonary bypass elicit a systemic inflammatory response and impair neutrophil chemotaxis in neonatal pigs?
Population
Neonatal pigs (n=27)
Comparison
Sternotomy and cardiopulmonary bypass (CPB) vs Sternotomy alone (sham group)
Design
Preclinical
Follow-up
Immediately after CPB
Authors
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Demonstrates CPB-induced inflammation and neutrophil impairment in neonatal pigs; hypothesis-generating for human translation.
Does cardiopulmonary bypass elicit a systemic inflammatory response and impair neutrophil chemotaxis in neonatal pigs?
Cardiopulmonary bypass in neonatal pigs elicits a systemic inflammatory response characterized by elevated IL-8 and IL-10 and temporarily impaired neutrophil chemotaxis.
Christensen et al. (2001) studied this question.
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