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January 23, 2018Journal of VirologyOpen Access

HAdV-41 infection of enterochromaffin cells induced serotonin secretion dose-dependently and activated EGCs, whereas control infection with HAdV-5 did not induce serotonin secretion.

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Population

Human midgut carcinoid cell line GOT1 (enterochromaffin cells) and enteric glia cells (EGCs)

Comparison

Human adenovirus 41 infection and purified… vs Control infection with HAdV-5 or uninfected cells

Design

Preclinical

Authors

SWSonja WesterbergMHMarie HagbomVLVesa Loitto

Discussion

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Overview

Does not yet inform clinical diarrhea management; leaves open a serotonin-EGC mechanism for HAdV-41 in animal models.

Structured PICO

P
Population
Human midgut carcinoid cell line GOT1 (enterochromaffin cells) and enteric glia cells (EGCs)
I
Intervention
Human adenovirus 41 (HAdV-41) infection and purified HAdV-41 short fiber knob and hexon proteins
C
Comparator
Control infection with HAdV-5 or uninfected cells
O
Outcome
Serotonin release/secretion and enteric glia cell (EGC) activation (GFAP expression)surrogate

HAdV-41 infection stimulates serotonin secretion in human enterochromaffin cells and activates enteric glia cells, suggesting a potential mechanism for HAdV-41-induced diarrhea.

Cite This Study

Westerberg et al. (2018) studied this question.

synapsesocial.com/papers/6a8661c0894d3eb3a35af352https://doi.org/10.1128/jvi.00026-18
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