Key result
Cryo-EM of enteric adenovirus F41 reveals a pH-resistant capsid explaining its gastrointestinal tropism.
Why the study?
Enteric human adenoviruses F40 and F41 are a leading cause of pediatric diarrhea, but the structural basis for their divergence in tissue tropism and pathogenicity from respiratory and ocular types was unknown.
Population
Enteric human adenovirus 41 (HAdV-F41)
Design
Cryo-EM structural analysis
Authors
Loading...
May inform enteric adenovirus vector design; leaves open clinical translation pending further studies.
The cryo-EM structure of HAdV-F41 provides the structural basis for its adaptation to a fundamentally different tissue tropism compared to respiratory and ocular adenoviruses.
Rafie et al. (2020) studied Enteric human adenovirus 41 infection. Cryo-EM structural analysis was evaluated on Virion structure at pH 7.4 and pH 4.0. Cryo-EM structural analysis of enteric human adenovirus F41 reveals a pH-resistant capsid with extensive surface remodeling and a unique arrangement of protein IX, explaining its gastrointestinal tropism.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: