Why the study?
Does dietary salt consumption exert significant biological effects on cardiovascular ageing independent of changes in blood pressure?
Does dietary salt consumption exert significant biological effects on cardiovascular ageing independent of changes in blood pressure?
This review highlights a potential blood pressure-independent mechanism by which dietary salt may drive cardiovascular ageing through reactive oxygen species generation.
Does not support changing salt recommendations; leaves open whether sodium metabolism drives cardiovascular ageing via reactive oxygen species independent of blood pressure.
Opinions about the impact of dietary salt on blood pressure have dominated the debate regarding 'salt sensitivity', which can be broadly defined as the blood pressure response to changes in sodium intake among individuals in a population. However, the larger question is whether salt consumption exerts significant biological effects independent of changes in blood pressure. Provisional answers to this question are reviewed based on newly discovered links between sodium metabolism and the generation of reactive oxygen species. These links suggest that, in a subset of the general population, salt consumption is a determinant in cardiovascular ageing.
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Abraham Aviv (2002) studied this question.
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