This review outlines the structure and function of HCN pacemaker channels in the mammalian brain and proposes their involvement in absence epilepsy.
In this review we describe the molecular structure of the hyperpolarization-activated cAMP-dependent I h , or HCN, pacemaker channel. We discuss the channel functions and its subunit composition. Also, we hypothesize that spike-wave discharges in absence epilepsy are caused by these I h channels located on the neurons of the thalamic reticular nucleus and layers three, four, and five of the somatosensory cortex. We describe the role of I h channels on reticular and cortical neurons in normal behavior.
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Bazyan et al. (2010) studied this question.
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