Population
A7r5 smooth muscle cells and BC3H1 cells (a cell line expressing Ca channels of the skeletal muscle type)
Comparison
Internal and external application of-202,791… vs Internal vs external application
Design
Preclinical
Authors
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Localizes dihydropyridine agonist binding to external membrane surface; leaves open relevance to human cardiovascular therapeutics.
The binding site for agonist dihydropyridines on calcium channels in smooth and skeletal muscle cells is located close to the external surface of the membrane.
Strübing et al. (1993) studied this question.
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