What question did this study set out to answer?

To evaluate whether a persistent or latent viral infection serves as a causative factor in amyotrophic lateral sclerosis (ALS).

November 1, 1973Archives of Neurology

Cultures of Tissues From Patients With Amyotrophic Lateral Sclerosis

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To evaluate whether a persistent or latent viral infection serves as a causative factor in amyotrophic lateral sclerosis (ALS).
Established cell cultures from tissues of nine patients with ALS and maintained them for several months to over one year to observe viral emergence.
Measured serum antibody titers against 15 viral agents in 34 patients with ALS and compared them against matched control subjects.
Long-term tissue cultures from nine ALS patients revealed no detectable evidence or signs of a viral cause.
Serum antibody titers against 15 viral agents did not differ significantly between 34 patients with ALS and matched controls.

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Implication

Case-control study reveals no evidence of viral infection in tissue cultures or antibody titers in amyotrophic lateral sclerosis, suggesting common viral pathogens do not drive the disease.

Cite This Study

Cremer et al. (1973) studied this question.

synapsesocial.com/papers/6a866745894d3eb3a35af6bc https://doi.org/10.1001/archneur.1973.00490290071009

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Implication

Case-control study reveals no evidence of viral infection in tissue cultures or antibody titers in amyotrophic lateral sclerosis, suggesting common viral pathogens do not drive the disease.

Cultures of Tissues From Patients With Amyotrophic Lateral Sclerosis

Key Points

Discussion

Implication

Cite This Study

Cultures of Tissues From Patients With Amyotrophic Lateral Sclerosis

Key Points

Discussion

Implication

Cite This Study

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