Full-length Myo10, but not the newly identified headless isoform, localizes to filopodial tips and undergoes intrafilopodial motility in neurons, suggesting a role in neuronal actin dynamics.
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Motor domain requirement distinguishes Myo10 isoforms in neuronal filopodia; leaves open isoform roles in cardiovascular actin dynamics.
Sousa et al. (2005) studied this question.
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