Why the study?
Does resistin decrease eNOS expression in human coronary artery endothelial cells?
Population
Human coronary artery endothelial cells and atherosclerotic regions of human aorta and carotid arteries
Comparison
Human recombinant resistin protein for 24 h vs Untreated cells (implied control)
Design
Preclinical
Follow-up
24 hours (in vitro)
Authors
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Resistin may promote endothelial dysfunction via eNOS suppression; hypothesis-generating for its role in human cardiovascular disease.
Does resistin decrease eNOS expression in human coronary artery endothelial cells?
Resistin directly induces eNOS downregulation through oxidative stress and activation of p38 and JNK in human coronary artery endothelial cells, providing a potential mechanism for resistin-induced endothelial dysfunction.
Chen et al. (2010) studied this question.
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