Why the study?
Does 2D speckle tracking echocardiography identify impaired left ventricular twist and rotation in patients with isolated left ventricular noncompaction compared to healthy volunteers?
Does 2D speckle tracking echocardiography identify impaired left ventricular twist and rotation in patients with isolated left ventricular noncompaction compared to healthy volunteers?
2D speckle tracking demonstrates significantly reduced apical rotation and left ventricular twist in patients with LVNC and systolic dysfunction, which may aid in diagnosis and risk stratification.
Speckle tracking may detect LV twist abnormalities in LVNC; leaves open diagnostic or prognostic utility pending prospective validation.
CĂl prĂĄce: PĹedmÄtem naĹĄĂ studie bylo hodnocenĂ rotaÄnĂho pohybu myokardu levĂŠ komory v dlouhĂŠ ose u pacientĹŻ postiĹženĂ˝ch non-kompaktnĂ kardiomyopatiĂ (LVNC) a jejich srovnĂĄnĂ s parametry zjiĹĄtÄnĂ˝mi u zdravĂ˝ch dobrovolnĂkĹŻ.Soubor a metodika: Do studie bylo zaĹazeno osm pacientĹŻ s LVNC potvrzenou echokardiograficky a magnetickou rezonancĂ (prĹŻmÄrnĂ˝ vÄk 41 ± 19 let, ÄtyĹi muĹži, ejekÄnĂ frakce [EFLK] 45 ± 25 %). NemocnĂ byli rozdÄleni na skupinu A s EFLK > 50 % (ÄtyĹi pacienti, jeden muĹž) a skupinu B s EFLK < 50 % (ÄtyĹi pacienti, tĹi muĹži). Ke kaĹždĂŠ z obou skupin byli pĹiĹazeni vÄkovÄ a pohlavĂm odpovĂdajĂcĂ zdravĂ dobrovolnĂci. ZamÄĹili jsme se na vyĹĄetĹenĂ twistu myokardu, rotacĂ hrotu a baze levĂŠ komory, ÄasĹŻ k dosaĹženĂ maximĂĄlnĂ apikĂĄlnĂ, maximĂĄlnĂ bazĂĄlnĂ rotace a twistu myokardu, dĂĄle pak na korelace mezi systolickou funkcĂ, rotacĂ jednotlivĂ˝ch rovin a twistem levĂŠ komory.VĂ˝sledky: SrovnĂĄnĂm pacientĹŻ s LVNC se zdravĂ˝mi dobrovolnĂky jsme zjistili statisticky vĂ˝znamnĂŠ snĂĹženĂ systolickĂŠ funkce (p = 0,004), vÄtĹĄĂ diastolickĂ˝ rozmÄr (p = 0,045) a snĂĹženĂ apikĂĄlnĂ rotace (p = 0,01). Twist levĂŠ komory byl signifikantnÄ snĂĹžen ve skupinÄ pacientĹŻ s LVNC a systolickou dysfunkcĂ (p = 0,04). Byla zjiĹĄtÄna statisticky vĂ˝znamnĂĄ korelace mezi systolickou funkcĂ a apikĂĄlnĂ rotacĂ levĂŠ komory.ZĂĄvÄr: NaĹĄe studie prokĂĄzala vĂ˝znamnĂ˝ pokles apikĂĄlnĂ rotace a mechanismu twist levĂŠ komory, mÄĹenĂŠ metodou 2D speckle tracking u pacientĹŻ s LVNC a snĂĹženou systolickou funkcĂ levĂŠ komory. MÄĹenĂ tÄchto parametrĹŻ by mohlo pĹispÄt k pĹesnÄjĹĄĂ diagnostice a rizikovĂŠ stratifikaci pacientĹŻ trpĂcĂch tĂmto onemocnÄnĂm.
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Rudolecká et al. (2014) studied this question.
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