Why the study?
Does discontinuation of clopidogrel for 7 days or longer increase the risk of perioperative stent thrombosis in patients with recent DES implantation?
Population
141 patients who underwent surgery requiring discontinuation of a dual antiplatelet agent within 12 months…
Comparison
Discontinuation of clopidogrel for 7 days or… vs Discontinuation of clopidogrel for less than 7…
Design
Cohort
Follow-up
perioperative period
Authors
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Prolonged clopidogrel discontinuation was associated with stent thrombosis after DES; leaves open optimal perioperative management pending randomized data.
Does discontinuation of clopidogrel for 7 days or longer increase the risk of perioperative stent thrombosis in patients with recent DES implantation?
Prolonged discontinuation of clopidogrel (≥7 days) and the use of a Taxus stent are strong independent predictors of perioperative stent thrombosis in patients with recent DES implantation.
Rhee et al. (2008) studied this question.
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