Why the study?
Does ceasing clopidogrel without alternative anti-thrombotic prophylaxis increase the risk of myocardial infarction in patients with drug-eluting stents undergoing non-cardiac surgery?
Does ceasing clopidogrel without alternative anti-thrombotic prophylaxis increase the risk of myocardial infarction in patients with drug-eluting stents undergoing non-cardiac surgery?
Ceasing clopidogrel without alternative anti-thrombotic prophylaxis prior to non-cardiac surgery in patients with drug-eluting stents carries a high risk (20%) of myocardial infarction due to stent thrombosis.
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Perioperative clopidogrel cessation without alternative may heighten stent thrombosis risk in DES patients; hypothesis-generating and should not yet change practice.
Conroy et al. (2007) studied this question.
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