October 1, 1996Cardiovascular ResearchOpen Access

The role of nitric oxide and cell adhesion molecules on the microcirculation in ischaemia-reperfusion

View Full Paper

Ask AI

Bookmark

Why the study?

Does treatment with nitric oxide or cell adhesion molecule blockers prevent reperfusion injury in ischaemic vasculature?

Population

Ischaemic vasculature (coronary and mesenteric microcirculation) undergoing reperfusion

Design

Review

Authors

ALA. M. LeferThomas Jefferson University DLDavid J. LeferHeart Failure & Transplant

Discussion

Member takes

Implication

Hypothesis-generating for pre-reperfusion NO or CAM blockade; clinical trials needed before any practice change.

Structured PICO

Does treatment with nitric oxide or cell adhesion molecule blockers prevent reperfusion injury in ischaemic vasculature?

Population

Ischaemic vasculature (coronary and mesenteric microcirculation) undergoing reperfusion

Intervention

Treatment with nitric oxide (NO), an organic NO donor, L-arginine, or specific blockers of cell adhesion molecules (CAMs) given just prior to reperfusion

Outcome

Cardiac necrosis / reperfusion injurysurrogate

Nitric oxide supplementation or cell adhesion molecule blockade prior to reperfusion represents a promising approach to attenuate ischaemia-reperfusion injury and cardiac necrosis.

Cite This Study

Lefer et al. (1996) studied this question.

synapsesocial.com/papers/6a868bbf4b115576a3d0a552 https://doi.org/10.1016/s0008-6363(96)00073-9

View Full Paper

Ask AI

Bookmark

The role of nitric oxide and cell adhesion molecules on the microcirculation in ischaemia-reperfusion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The role of nitric oxide and cell adhesion molecules on the microcirculation in ischaemia-reperfusion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider