What question did this study set out to answer?

To assess and compare the extent of myocardial damage and electrical instability induced by various damped sine and trapezoidal defibrillator waveforms.

July 1, 1989European Heart Journal

Cardiac injury with damped sine and trapezoidal defibrillator waveforms

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Why the study?

Do different defibrillator waveforms cause varying degrees of cardiac damage in anaesthetized greyhounds?

Population

49 anaesthetized greyhounds

Comparison

Five shocks from a defibrillator delivering one… vs No shocks (control group)

Design

Preclinical

Follow-up

3 days

Authors

CWCarol M. WilsonBelfast Health and Social Care Trust ABA BaileyThe University of Texas Southwestern Medical Center JAJD AllenUniversity of Southampton

Discussion

Member takes

Implication

Findings in anaesthetized dogs should not alter clinical defibrillator use; leaves open whether waveform differences affect human myocardial injury.

Key Points

To assess and compare the extent of myocardial damage and electrical instability induced by various damped sine and trapezoidal defibrillator waveforms.
Assigned 49 anaesthetized greyhounds to receive either no shocks (control group) or five shocks from a defibrillator delivering one of five waveforms: Lown, Edmark, or Belfast damped sine waves, or 5 ms or 20 ms trapezoidal waveforms.
Monitored post-shock ventricular ectopic counts and ST-segment elevation, and subsequently examined macroscopic heart damage in the 36 surviving dogs at 3 days.
Belfast (21.1 ± 2.9 g) and Edmark (16.0 ± 3.7 g) waveforms caused significantly greater macroscopic myocardial damage than the Lown waveform (3.5 ± 1.3 g; P < 0.01).
The 20 ms trapezoidal waveform caused significantly more myocardial damage (8.1 ± 3.1 g) than the 5 ms pulse (0.7 ± 1.3 g; P < 0.05).
Ventricular ectopic counts at 2 and 72 hours, as well as early ST-segment elevations, were significantly higher in the Belfast and Edmark groups than in the Lown group (P < 0.05).

Structured PICO

Do different defibrillator waveforms cause varying degrees of cardiac damage in anaesthetized greyhounds?

Population

49 anaesthetized greyhounds

Intervention

Five shocks from a defibrillator delivering one of five waveforms (Lown, Edmark, Belfast damped sine waveforms; 5 and 20 ms trapezoidal waveforms)

Comparator

No shocks (control group)

Outcome

Macroscopic cardiac damage at 3 dayssurrogate

Different defibrillator waveforms cause varying degrees of myocardial damage, with Belfast and Edmark waveforms causing more damage than Lown waveforms, and longer trapezoidal pulses causing more damage than shorter ones.

Cite This Study

Wilson et al. (1989) studied this question.

synapsesocial.com/papers/6a868cba1d4e7816c90cf8db https://doi.org/10.1093/oxfordjournals.eurheartj.a059540

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Implication

Findings in anaesthetized dogs should not alter clinical defibrillator use; leaves open whether waveform differences affect human myocardial injury.

Cardiac injury with damped sine and trapezoidal defibrillator waveforms

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cardiac injury with damped sine and trapezoidal defibrillator waveforms

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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