What question did this study set out to answer?

This study aims to evaluate the relationship between pulse duration and energy thresholds required for successful defibrillation using specific waveforms in dogs.

July 1, 1988Pacing and Clinical Electrophysiology

Strength‐Duration Curves of Fixed Pulse Width Variable Tilt Truncated Exponential Waveforms for Nonthoracomy Internal Defibrillation in Dogs

Q: What is the clinical evidence from this study?

Study design: Other. Population: Induced fibrillation (n=6). Intervention: Truncated monophasic pulses of varying durations vs. Different pulse durations compared to each other. Primary outcome: Minimum peak voltage and energy resulting in defibrillation (p=<0.05).

View Full Paper

Ask AI

Bookmark

Key result

Shorter pulse durations of 2.5-15 msec had significantly lower energy thresholds for defibrillation than 20 msec shocks (P<0.05), with midrange shocks offering the best combination of requirements.

Why the study?

What is the optimal pulse duration for nonthoracotomy internal defibrillation using truncated monophasic pulses in a canine model?

Population

6 anesthetized dogs

Comparison

Truncated monophasic pulses of 2.5-20 msec in… vs Different pulse durations compared against each…

Design

Preclinical, Various durations were tested randomly

Authors

PCPeter D. ChapmanGeorgia Institute of Technology JWJule N. WetherbeeAurora Health Care JVJames W. VetterMedical College of Wisconsin

Discussion

Member takes

Implication

Animal results should not change clinical defibrillation practice; leaves optimal pulse duration open for human trials.

Key Points

This study aims to evaluate the relationship between pulse duration and energy thresholds required for successful defibrillation using specific waveforms in dogs.
Six anesthetized dogs were used in the defibrillation trials.
Truncated monophasic pulses of varying durations (2.5-20 msec) were tested.
Defibrillation thresholds were measured based on voltage and energy required for successful shocks.
Shorter pulse durations (2.5-15 msec) required significantly lower energy than 20 msec pulses (P<0.05).
Minimum voltage thresholds occurred between 7.5-12.5 msec, while the highest thresholds were at the shortest and longest pulse durations.
5 to 15 msec pulses showed significantly lower voltage thresholds compared to 2.5 msec pulses (P<0.05).

Structured PICO

What is the optimal pulse duration for nonthoracotomy internal defibrillation using truncated monophasic pulses in a canine model?

Population

6 anesthetized dogs undergoing induced fibrillation to test various pulse durations for internal defibrillation.

Intervention

Truncated monophasic pulses of 2.5-20 msec in duration for nonthoracotomy internal defibrillation using a 4 cm2 RV catheter electrode and a 13.9 cm2 subcutaneous chest wall patch

Comparator

Different pulse durations (2.5-20 msec) compared against each other

Outcome

Minimum peak voltage and energy resulting in defibrillationsurrogate

Main Result

p-value: p=<0.05

Midrange pulse durations (5-15 msec) provide the optimal combination of low average current and energy requirements for nonthoracotomy internal defibrillation in a canine model.

Cite This Study

Chapman et al. (1988) studied Induced fibrillation (n=6). Truncated monophasic pulses of varying durations vs. Different pulse durations compared to each other was evaluated on Minimum peak voltage and energy resulting in defibrillation (p=<0.05). Shorter pulse durations of 2.5-15 msec had significantly lower energy thresholds for defibrillation than 20 msec shocks (P<0.05), with midrange shocks offering the best combination of requirements.

synapsesocial.com/papers/6a2178f6af2526c2895fa1a2 https://doi.org/10.1111/j.1540-8159.1988.tb03950.x

View Full Paper

Ask AI

Bookmark

Strength‐Duration Curves of Fixed Pulse Width Variable Tilt Truncated Exponential Waveforms for Nonthoracomy Internal Defibrillation in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Strength‐Duration Curves of Fixed Pulse Width Variable Tilt Truncated Exponential Waveforms for Nonthoracomy Internal Defibrillation in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider