October 1, 1989Circulation ResearchOpen Access

Contractile shortening response of ventricular cells to extracellular acidosis. Evidence for two-site control of H+-Ca2+ interaction.

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Population

Single isolated ventricular cells from rabbit

Comparison

Extracellular acidosis vs Baseline pH 7.5

Design

Preclinical

Follow-up

30 seconds

Authors

GLG. A. LangerUniversity of Southern California TRT. L. RichUniversity of California, Los Angeles SJSungchul JiRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Preclinical model only; leaves open human translation of rapid H+-Ca2+ effects on contraction.

Structured PICO

Population

Single isolated ventricular cells from rabbit

Intervention

Extracellular acidosis (pHo decreased to 7.0, 6.5, 6.0, and 5.5 at 8 [Ca]o levels)

Comparator

Baseline pH 7.5

Outcome

Contractile shortening response and calcium current measured 30 seconds after pHo decreasesurrogate

Extracellular acidosis rapidly alters ventricular cell contraction and calcium current, which can be predicted by a two-site model of H+-Ca2+ interaction.

Cite This Study

Langer et al. (1989) studied this question.

synapsesocial.com/papers/6a868cf8d2b0081f1417a8bf https://doi.org/10.1161/01.res.65.4.894

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Contractile shortening response of ventricular cells to extracellular acidosis. Evidence for two-site control of H+-Ca2+ interaction.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Contractile shortening response of ventricular cells to extracellular acidosis. Evidence for two-site control of H+-Ca2+ interaction.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider