Why the study?
Is underweight status associated with a higher risk of all-cause mortality in Asian patients with HFpEF compared to normal and overweight status?
Is underweight status associated with a higher risk of all-cause mortality in Asian patients with HFpEF compared to normal and overweight status?
Underweight status is a strong independent predictor of all-cause mortality in Asian patients with HFpEF.
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Underweight status was associated with higher mortality; hypothesis-generating and should not yet change practice.
), normal weight (18.5 ≤ BMI < 23), and overweight (23 ≤ BMI). The underweight group consisted of 187 patients (22%). Over a mean follow-up of 407 days, 105 deaths were reported as all-cause mortality. On multivariable Cox analysis, the underweight group was determined to be significantly associated with higher risk of all-cause mortality than the normal and overweight groups (Hazard ratios [HR]: 2.33; 95% confidence intervals [CI]: 1.45-3.75, P < 0.001; HR: 3.54; 95% CI: 1.99-6.29, P < 0.001, respectively), after adjustment for age, sex, vital signs, and comorbidities.Underweight is a useful predictor of poor prognosis in patients with HFpEF in Asian population.
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Matsuhiro et al. (2021) studied this question.
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