Comparison of Ketofoland Propofol in Intracranialaneurysmalclipping Surgery: A Prospective Randomized Control Study

Background: Haemodynamic stability is the major goal of anaesthesia during intracranial aneurysm clipping . In the present study, we compared the effects of ketofol with propofol alone, used as an induction and maintenance agent during surgical clipping of intracranial aneurysm. Material and methods - Forty patients aged 18 to 75 years, posted for aneurysm neck clipping following aneurysmal Subarachnoid haemorrhage (SAH) were included in the study. The patients were randomized into two groups. One group received combination of ketamine and propofol (1:5 ratio) (Group KP) and the other propofol (Group P) for induction and maintenance of anaesthesia. Results - Combination of Ketamine and propofol ( in the ratio of 1:5) which was used in this study provided for better maintenance of Mean Arterial Pressure(MAP) during induction and maintenance of anaesthesia. Conclusion – Ketofol compared to propofol alone provides better hemodynamic stability on induction as well as during maintenance of anaesthesia in intracranial aneurysmal clipping surgery without increasing intracranial pressure.