Isoproterenol mimics calcium preconditioning-induced protection against ischemia

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Structured PICO

Population

Langendorff-perfused rat hearts subjected to 40 min of global ischemia followed by 30 min of reperfusion

Intervention

Isoproterenol (0.1 micromol/l) pretreatment or Ca2+ preconditioning (3 cycles of 1-min Ca2+ depletion and 5-min Ca2+ repletion)

Comparator

Nontreated ischemia/reperfusion (I/R) hearts

Outcome

Left ventricular functional recovery, lactate dehydrogenase release, and ATP content preservationsurrogate

Transient elevation of intracellular calcium via low-dose isoproterenol protects against ischemic injury through PKC activation in a rat heart model.

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May protect rat hearts from I/R via PKC; hypothesis-generating and should not change clinical practice.

Miyawaki et al. (1997) studied this question.

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