Population
Perfused beating rabbit atria
Design
Preclinical
Authors
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Supports distinct particulate vs soluble guanylyl cyclase roles in atrial cAMP; leaves open translation to human physiology.
Particulate and soluble guanylyl cyclase activations act as high and low gain switches, respectively, for regulating cAMP levels and contractile and secretory functions in the cardiac atrium.
Wen et al. (2004) studied this question.
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