Key result
Extracellular application of the PDE2 inhibitor EHNA increased the amplitude of basal L-type calcium current by approximately 80% in freshly isolated human atrial myocytes.
Why the study?
Does EHNA increase basal L-type Ca2+ current in human atrial myocytes?
Does EHNA increase basal L-type Ca2+ current in human atrial myocytes?
Answers are grounded in this paper and cite their sources.
Basal L-type calcium current is controlled by PDE2 activity in human atrial myocytes, but not in rat cardiac myocytes, highlighting species-specific regulation of cardiac electrophysiology.
No abstract yet. The journal hasn't published one we can show.
No takes yet. Share an insight, caveat, or question.
Rivet-Bastide et al. (1997) studied Patients undergoing heart surgery (n=53). EHNA vs. Basal conditions (control solution) was evaluated on Amplitude of basal L-type Ca2+ current (ICa) (p=<0.05). Extracellular application of the PDE2 inhibitor EHNA increased the amplitude of basal L-type calcium current by approximately 80% in freshly isolated human atrial myocytes.
Synapse has enriched 10 related papers. Consider them for comparative context: