Why the study?
Does labetalol prevent doxorubicin-induced cardiotoxicity in a rat model?
Population
30 Wale-Sprague male rats
Comparison
Labetalol daily for 10 days, with a single dose… vs Control group and doxorubicin-only group
Design
Preclinical
Follow-up
10 days
Authors
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Hypothesis-generating in rat model; should not change practice or guide therapy pending human trials.
Does labetalol prevent doxorubicin-induced cardiotoxicity in a rat model?
In a rat model, labetalol pre-treatment attenuated doxorubicin-induced cardiotoxicity as evidenced by improved cardiac biomarkers and histopathology.
Al‐kuraishy et al. (2015) studied this question.
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