Why the study?
Does alpha-trinositol infusion improve regional and cardiac haemodynamics in conscious rats?
Population
Male, Long Evans rats chronically instrumented for the measurement of regional and cardiac haemodynamics
Comparison
Alpha-trinositol via chronic infusion vs Vehicle (sterile saline at 0.3 ml h-1)
Design
Preclinical
Follow-up
Up to 48 hours
Authors
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Alpha-trinositol's vasodilatory and inotropic profile in rats is hypothesis-generating; leaves open translation to human haemodynamics.
Does alpha-trinositol infusion improve regional and cardiac haemodynamics in conscious rats?
High-dose alpha-trinositol infusion produces a unique cardiovascular profile characterized by significant regional vasodilation and increased cardiac inotropism without causing hypotension or tachycardia in conscious rats.
Gardiner et al. (1994) studied this question.
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