Why the study?
Does ET(A) receptor blockade with A-127722 reduce hypertension and renal lesions in male Sprague Dawley rats with chronic NOS inhibition?
Population
Male Sprague Dawley rats
Comparison
A-127722 (ET receptor blocker) 30 mg/kg per day… vs L-NNA alone, and untreated control
Design
Preclinical
Follow-up
3 weeks
Authors
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ET(A) blockade merits preclinical follow-up in hypertensive nephropathy; leaves open human translation from this rat model.
Does ET(A) receptor blockade with A-127722 reduce hypertension and renal lesions in male Sprague Dawley rats with chronic NOS inhibition?
ET(A) receptor blockade with A-127722 partially prevents hypertension and completely prevents proteinuria and glomerular ischemia in a rat model of chronic NOS inhibition.
Verhagen et al. (1998) studied this question.
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