Why the study?
Do PD 142893, SB 209670, and BQ 788 selectively antagonize vascular endothelial versus vascular smooth muscle ET(B) receptors in rats?
Population
Isolated perfused rat kidney and isolated perfused rat mesentery
Comparison
PD 142893, SB 209670, and BQ 788 with increasing… vs Sarafotoxin S6c in the absence of antagonist
Design
Preclinical
Authors
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May inform endothelium-selective ET(B) antagonist development; leaves open translation to human cardiovascular applications.
Do PD 142893, SB 209670, and BQ 788 selectively antagonize vascular endothelial versus vascular smooth muscle ET(B) receptors in rats?
PD 142893, SB 209670, and BQ 788 selectively antagonize endothelial ET(B)-receptor activity over smooth-muscle ET(B)-receptor activity in rat models.
Schroeder et al. (1998) studied this question.
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