Why the study?
Does SB 209670 prevent Endothelin-1-induced fatal ventricular fibrillation and coronary ischemia in anesthetized dogs?
Does SB 209670 prevent Endothelin-1-induced fatal ventricular fibrillation and coronary ischemia in anesthetized dogs?
SB 209670 completely abolishes ET-1-induced fatal ventricular arrhythmias in anesthetized dogs, suggesting endothelin receptor antagonists may have therapeutic potential for cardiac rhythm disturbances.
No takes yet. Share an insight, caveat, or question.
No immediate clinical implications for arrhythmia management; leaves open translation of canine endothelin antagonism to human trials.
Douglas et al. (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: