Why the study?
Do LH and GNRH receptors have a potential role in regulating aldosterone secretion in primary aldosteronism?
Population
1 index case with primary aldosteronism arising during pregnancy, 11 other patients with PA, and 5 controls…
Comparison
GNRH test vs Healthy controls and normal adrenal tissues
Design
Case_series
Authors
Loading...
May indicate GNRHR role in aldosterone secretion in select APA; hypothesis-generating for pregnancy-associated PA and does not change practice.
Do LH and GNRH receptors have a potential role in regulating aldosterone secretion in primary aldosteronism?
Aberrant expression of LH and GNRH receptors in a subset of aldosterone-producing adenomas may modulate aldosterone secretion, which is particularly relevant in pregnancy-associated primary aldosteronism.
Albiger et al. (2011) studied this question.