Population
Isolated segments of porcine vena cordis magna (n=206 for Substance P experiment)
Comparison
Nitrovasodilators (S-nitroso-N-acetyl-D,L-penicil… vs Endothelium-denuded segments versus intact…
Design
Preclinical
Authors
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Endothelial modulation may influence nitrate tolerance in veins; extends animal mechanistic data but leaves open human translation.
The intact endothelium in porcine veins attenuates the relaxant potency of nitrovasodilators, likely due to endogenous nitric oxide production affecting the cGMP system or inhibiting nitrate bioactivation.
Kojda et al. (1994) studied this question.
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