Why the study?
Does spironolactone treatment alter digoxin kinetics in human subjects?
Population
8 subjects
Comparison
Long-term treatment with spironolactone vs Same subjects prior to spironolactone treatment
Design
Cohort
Authors
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Alerts to possible digoxin-spironolactone interaction; leaves open need for randomized dose-adjustment trials.
Does spironolactone treatment alter digoxin kinetics in human subjects?
Co-administration of spironolactone significantly alters digoxin pharmacokinetics, suggesting a need for reduced digoxin loading and maintenance doses to prevent toxicity.
Waldorff et al. (1978) studied this question.
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