Why the study?
Does the combination of quinidine and spironolactone alter digoxin kinetics compared to digoxin alone in normal subjects?
Population
6 normal subjects
Comparison
Digoxin 1.0-mg intravenous dose combined with… vs Digoxin 1.0-mg intravenous dose alone
Design
Other
Authors
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May require digoxin dose adjustment with coadministration; leaves open effects in heart failure populations.
Does the combination of quinidine and spironolactone alter digoxin kinetics compared to digoxin alone in normal subjects?
The combination of quinidine and spironolactone significantly alters digoxin kinetics, necessitating dose reduction and careful monitoring when these drugs are co-administered.
Fenster et al. (1984) studied this question.
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