Population
Isolated, perfused rabbit hearts
Design
Preclinical
Authors
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Caution against extrapolating rabbit calcium heterogeneity to humans; leaves open relevance to arrhythmia mechanisms or targeted therapies.
In isolated rabbit hearts, calcium uptake rate constants are highest in the septum and lowest in the atria, while equilibrium calcium content follows the reverse order.
Saari et al. (1980) studied this question.
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