In the isolated rabbit heart, the rate constants for calcium content build-up and contractile force build-up during calcium uptake are similar.
Answers are grounded in this paper and cite their sources.
Does not inform clinical calcium management; leaves open translation of rabbit heart kinetics to human or in vivo settings.
Build-up of whole heart calcium content and contractile force was studied in the isolated, perfused rabbit heart during uptake of calcium ion. Calcium content increased in one exponential phase (rate constant 0.119 s −1 ) from a constant unexchangeable pre-build-up value. Contractile force increased in one exponential phase (rate constant 0.084 s −1 ) from its resting value. The rate constants for calcium content and contractile force build-up did not differ significantly. A difference in the above build-up rate constants from those of calcium and force decay observed in prior work in the same preparation was presumed due to dependence of capillary permeability on calcium concentration.
No takes yet. Share an insight, caveat, or question.
Saari et al. (1972) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: