December 1, 1968The Journal of General PhysiologyOpen Access

Correlation of Contractile Force with a Calcium Pool in the Isolated Cat Heart

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Population

Isolated, gas-perfused cat hearts

Comparison

Preperfusion with substrate-free Krebs solution… vs Different calcium concentrations

Design

Preclinical

Follow-up

up to 120 minutes

Authors

LBLeslie E. BaileyDalhousie University PDPeter E. DreselDalhousie University

Discussion

Member takes

Implication

Does not inform clinical practice; hypothesis-generating for compartmental Ca in myocardial contractility.

Structured PICO

Population

Isolated, gas-perfused cat hearts

Intervention

Preperfusion with substrate-free Krebs solution containing varying calcium concentrations (0, 1.25, 2.5, 5.0 or 10.0 mEq/liter), followed by gas-perfusion for up to 120 min, then zero-Ca Krebs solution

Comparator

Different calcium concentrations (0, 1.25, 2.5, 5.0 or 10.0 mEq/liter)

Outcome

Contractile force and calcium concentration in the effluent fluidsurrogate

Cellular calcium stores in a specific compartment correlate strongly with isometric contractile force in isolated cat hearts.

Cite This Study

Bailey et al. (1968) studied this question.

synapsesocial.com/papers/6a1e80ca1d1700dc279548c8 https://doi.org/10.1085/jgp.52.6.969

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Correlation of Contractile Force with a Calcium Pool in the Isolated Cat Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Correlation of Contractile Force with a Calcium Pool in the Isolated Cat Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider